Serum Transfusion in Hemophiliacs

Abstract

To study the effectiveness of serum transfusion in hemophiliacs, in vitro experiments and in vivo trials were carried out. In in vitro experiments, addition of one volume of serum shortened consisently the kaolin added partial thromboplastin time (kaolin PTT) of both hemophilia A and B plasmas. In the former, the shortening was the same as in the control plasma, but the elevation of AHG level was not seen in the mixture, while in the latter the shortening was more marked than in the control plasma and the PTC level was elevated. In in vivo studies, 80 ml of serum was transfused in each of the cases of hemophilia A and B. In the former, kaolin PTT was shortened from 119.0 to 92.0 sec., whereas the level of AHG was not changed. In the latter, kaolin PTT was shortened from 262.0 to 151.0 see, and the PTC level was elevated from less than 1% normal to 2.8% normal. Serum transfusion is thought to be an effective hemostatic procedure in hemophilia A and especially in hemophilia B.