1974 Volume 112 Issue 2 Pages 119-128
Changes in the cardiac output and blood flow in the renal, superior mesenteric and carotid arteries in anesthetized dogs were observed, using the noncannulating electromagnetic flow meter. Cyclic AMP, 10mg per kilogram of body weight, was given intravenously and the following results were obtained: 1) Cyclic AMP slightly decreased the heart rate, and increased the stroke volume and cardiac output. 2) Both systemic blood pressure and central venous pressure were decreased. 3) The renal blood flow decreased for the first few minutes, and increased after 10minutes, but the superior mesenteric and carotid blood flows increased. 4) Distribution ratio in the renal artery decreased for a short time, while those in the superior mesenteric and carotid arteries increased. 5) Cardiac output was depressed by propranolol (0.5mg/kg), but not enhanced by aminophylline (5mg/kg).
