Prolongation of Skin Graft Survival in Mice by 6-Mercaptopurine Riboside

Abstract

6-Mercaptopurine riboside (6-MPR), which is thought to be a powerful metabolic antagonist of the nucleic acid synthesis and to have a lower toxicity than 6-mercaptopurine (6-MP), prolongs the survival time of skin homografts in mice when administered after grafting. Treatment must be continued to maintain graft reliability.