The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
In Vivo Conjugation of 4-[14C] Cortisol by Cerebrospinal Fluid of Norman and Carbon Tetrachloride Impaired Dogs
SHIGERU ONO, HIROKO HIRANO, KIJURO OBARA, MASAKAZU KAMEI, ISAMU KAITO
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Keywords: cortisol, sulphote and glucuronide conjugation, cerebrospinal fluid
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1974 Volume 113 Issue 3 Pages 299-300

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Abstract
In vivo study on the conjugation of 4-[14C]cortisol in the cerebrospinal fluid (CSF) of normal and CCl4-treated dogs was carried out. Ten min after the injection of 4-[14C]cortisol, about 3 ml of CSF was withdrawn and conjugation of 4-[14C]cortisol was assayed. Both sulphate and glucuronide conjugations of cortisol in the CSF of the dog treated with CCl4 in vivo were found to be decreased as compared with those in the normal dog, indicating that conjugation of cortisol in the CSF is markedly influenced by liver dysfunction.
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