Abstract
Between October and December, 1973, an outbreak of epidemic keratoconjunctivitis occurred in a babies home in Sapporo. 28 out of 58 infants and children suffered from the disease. Infection seemed to have been transmitted within a room by hands of nursing staff with spread into other rooms through the dispensary. Clinical manifesta-tion in almost all of the Patients was pseudomembraneous conjunctivitis without apparent corneal opacities. None of them showed systemic symptoms. Virus isolation was attempted from eye swabs of 4 patients between 5 and 8 days after onset of the disease, and adenovirus type 8 was isolated from all of the specimens. It was found that there was no case of subclinical infection by the serologic tests. Consecutive serologic studies revealed a good neutralizing antibody response to adenovirus type 8 in the patients tested.
