The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
An IgG M-Component Reacting with Both Anti-κ and Anti-λ Light Chains in Multiple Myeloma
SEIJU ONODERA, RYUTARO INABA, ISAO SATO, KAZUYASU ENDO, TAKASHIRO SUZUKI, OSAMU KITAHARA, KATSUKO TAKAIIASHI, SHIGEO SUZUKI, YUKIO IMAMURA
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キーワード: multiple myeloma, IgG-IM component, reaction with both Anti-κ and anti-λ
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1976 年 120 巻 3 号 p. 269-275

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A patient with multiple myeloma who has an IgG-IM-component in serum reacting with both κ and λ light chains in im-munoelectrophoresis is presented. The possibility of ‘hybrid molecule (H2LκL λ)’ is strongly suspected. The absorption studies of the patient's serum employing Anti-κ and anti-A light chains, however, support the view that this apparently single M-component consists of two M-components, IgG 1-κ and IgG 1- λ. The reason why these two M-components possessed the identical electrophoretic mobility is unclear. The possibility is high that these two M-components are produced in the same cell.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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