Reversal of Prednisolone-Induced Inhibition of Intestinal Calcium-Binding Protein Synthesis by 1α-Hydroxycholecalciferol in Chicks

Abstract

Effects of prednisolone on the biochemical indices of blood serum, ash content in bones, calcium absorption and calcium-binding protein (CaBP) in the intestinal mucosa were studied. The oral administration of prednisolone (10mg/kg) for 2 weeks reduced CaBP content and calcium absorption to the level typical for D-avitaminosis. The oral administration of 1α-hydroxycholecalciferol (390pmoles/day) in combination with prednisolone for a week returned calcium absorption and CaBP to the control value.