Extraction of Fibronectin from Human Normal and Cirrhotic Livers

Abstract

ISEMURA, M., MUNAKATA, H., KOSAKAI, M., NOMOTO, M., AOYAGI, Y., ICHIDA, F., NAGAI, H., MOTOMIYA, M. and YOSIZAWA, Z. Extraction of Fibronectin from Human Normal and Cirrhotic Livers. Tohoku J. exp. Med., 1984, 144 (2), 217-218 -Tissue-associated fibronectin was extracted with 4M urea from human normal and cirrhotic livers. The results of rocket immunoelectrophoresis indicated that the amount of fibronectin in cirrhotic liver was twice as much as that in normal liver. The collagen content was much higher in cirrhotic than in normal livers. These data suggested an important role of fibronectin in tissue fibrosis.