The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Extraadrenal Immunohistochemical Distribution of Steroid 21-Hydroxylase in Human
HIRONOBU SASANONOBUAKI SASANO
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1988 Volume 154 Issue 1 Pages 21-28

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Abstract

SASANO, H. and SASANO, N. Extraadrenal Immunohistochemical Distribution of Steroid 21-Hydroxylase in Human. Tohoku J. exp. Med., 1988, 154 (1), 21-28 - Using an antibody against cytochrome P-450 specific for steroid 21- hydroxylase (P-450C21), extraadrenal distribution and localization of the enzyme were immunohistochemically examined on various normal human tissues. Immunoreactive P-450C21 was demonstrated in the renal tubular system, especially in distal tubules and cortical and medullary collecting tubules; excretory ducts including intercalated ducts of the pancreas and salivary glands; secretory ducts of the mammary glands. The immunoreactivity for P-450C21 was not present in the colon and liver. Transepithelial transport of sodium, potassium and hydrogen ions occurs in those sites where P-450C21 is present and mineralocorticoid receptors are presumed to be present. Relationship of extraadrenal 21-hydroxylase, which produces deoxycorticosterone locally, to a mineralocorticoid action is proposed.

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