The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Chronic Myelocytic Leukemia Probably Promoted by Growth Hormone
AKEMI ISHII, KAZUHIKO KAKUTA, SHIGERU TSUCHIYA, TASUKE KONNO
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Keywords: growth hormone, chronic myelocytic Leukemia, Phl chromosome
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1989 Volume 158 Issue 3 Pages 263-264

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Abstract

ISHII, A., KAKUTA, K., TSUCHIYA, S. and KONNO, T. Chronic Myelocytic Leukemia Probably Promoted by Growth Hormone. Tohoku J. Exp. Med., 1989, 158 (3), 263-264-The study shows clinical evidence that growth hormone (GH) presumably promoted Phl-positive chronic myelocytic leukemia in a 14-year-old boy who was receiving GH treatment for growth failure after surgery and irradiation for craniopharyngioma. Leukocytosis associated with immature myelocytic cells and low leukocyte alkaline phosphatase score appeared one year after GH treatment. Cytogenic study showed the presence of Phl chromosome.

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