The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Mechanisms of β-Adrenoceptor Mediated Increase in Delayed Rectifier Potassium Current
TOSHIHIKO IIJIMA, NORIO TAIRA
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キーワード: delayed rectifier potassium current (IK), isoproterenol, β-adrenoceptor, GTP-binding protein, forskolin
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1989 年 159 巻 4 号 p. 277-281

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IIJIMA, T. and TAIRA, N. Mechanisms of β-Adrenoceptor Mediated Increase in Delayed Rectifier Potassium Current. Tohoku J. Exp. Med., 1989, 159 (4), 277-281 -Experiments were carried out in single ventricular cells of the guinea-pig heart. Isoproterenol, forskolin, intracellularly applied cyclic AMP and 3-isobutyl-1-methylxanthine increased the delayed rectifier potassium current (IK). The effect of isoproterenol was abolished by intracellularly applied guanosine 5'-O-(3-thio-triphosphate). These results indicate that isoproterenol stimulates β-adrenoceptors to activate adenylate cyclase by mediation through the stimulatory GTP-binding protein, and causes an increase in intracellular cyclic AMP levels. Then IK is probably increased by phosphorylation of the IK-channel protein by cyclic AMP-dependent protein kinase.
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