Acute Megakaryoblastic Leukemia in Down Syndrome, Following Thrombocytopenia with Antiplatelet Antibody

Abstract

SUMI, S., OBAYASHI, M., MURAKAMI, M., ITO, J., OKADA, N. and SHIBATA, Y. Acute Megakaryoblastic Leukemia in Down Syndrome, Following Thrombocytopenia with Antiplatelet Antibody. Tohoku J. Exp. Med., 1990, 161(1), 65-67 - We report a case of acute megakaryoblastic leukemia (AMKL) with antiplatelet antibody in a boy with Down syndrome. When the patient was admitted, his platelet count was 1.3×10⁴/mm³ and antiplatelet antibody in the plasma was detected. Two months after admission, blasts, which showed positive reaction to both antiplatelet monoclonal antibody and platelet peroxidase, increased.