Abstract
1. In my experiment atropine was determined gravimetrically. Atropine sulphate is treated with an excess of phosphomolybdic acid and the precipitate is 2.5 times the exact amount of atropine.
2. Atropine is adsorbed by Dazol. 0.01 grm. of Dazol adsorbs 0.0023 grm. of atropine; 0.1 grm. of the former, 0.027 grm. of the latter; again 1.0 grm. of the former, 0.087 grm. of the latter. For the complete adsorption of the alkaloid, as large an amount (so many grams) of Dazol as 12-15 times the amount of atropine will be required.
3. The amount of atropine adsorbed by Dazol will be increased to a certain extent as the time of contact becomes longer. The adsorption by Dazol becomes larger to a certain extent, as the relative excess of atropine to Dazol is larger.
4. The adsorbed atropine will be extracted by means of hydrochloric acid, alkali and ammonium chloride solutions.
5. Dazol-atropine, given per os, is dissociated at a slow rate within the body and manifests its effect only slowly, so that a peroral administration of it causes a much longer life, in spite of its use in the amount corresponding to the lethal dose of atropine.
6. The alleged deterioration of an aqueous solution of atropine sulphate was not shown by the method of the isolated frog heart of Yagi and Straub.
7. Atropine, stomachally administered, causes a rapid fall of blood pressure, while Dazol-atropine causes only a slight and gradual fall, and thus a longer life than 24 hours even with a lethal dose is made possible. Dazol-atropine is thus dissociated at a slow rate and manifests its effect only slowly.
