The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Alteration of Ammonia and Carnitine Levels in Short-Term Treatment with Pivalic Acid-Containing Prodrug
TETSUYA ITO, NARUJI SUGIYAMA, MASANORI KOBAYASHI, KIYOSHI KIDOUCHI, TAMIKO ITOH, OSAMU UEMURA, KOHACHIRO SUGIYAMA, HAJIME TOGARI
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キーワード: carnitine deficiency, pivalic acid, hyperammonemia
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1995 年 175 巻 1 号 p. 43-53

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ITO, T., SUGIYAMA, N., KOBAYASHI, M., KIDOUCHI, K., ITOH, T., UEMURA, O., SUGIYAMA, K. and TOGARI, H. Alteration of Ammonia and Carnitine Levels in Short-Term Treatment with Pivalic Acid-Containing Prodrug. Tohoku J. Exp. Med., 1995, 175 (1), 43-53-We investigated the influence on mitochondrial functions in carnitine deficiency caused by short-term treatment of cefteram-pivoxil (CFTM-PI) which is one of pivaloyloxymethyl-esterified antibiotics in adult volunteers and diseased children. Administration of CFTM-PI caused hypocarnitinemia in all cases, and we observed a significant elevation of blood ammonia levels compared with those after its withdrawal in diseased children. A significant negative correlation was found between the levels of serum free carnitine and blood ammonia, and a positive correlation was observed between serum carnitine and blood glutamine levels in all adult samples and samples during administration in diseased children. Our data suggest that these antibiotic medications affect the mitochondrial function even in a short-term treatment and that L-carnitine supplementation would be necessary for patients treated with CFTM-PI.
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    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.


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