Abstract
In normal rabbits pilocarpine was proved effective in causing an increase of the blood sugar concentration if hypodermically given in a dose over 2 mgrma. per kilo of body weight, and the hyperglycaemic effect of physostigmine is certain if 0.5 mgrm. per kilo is given under skin.
By sectioning the splanchnic nerves bilaterally or removing both suprarenal glands one is able to diminish largely the increase of the blood sugar content by pilocarpine or physostigmine, but not completely. Removing the suprarenal glands is more effective in that case.
On receiving pilocarpine or physostigmine the epinephrine load of the suprarenal glands of rabbits, innervated normally, diminishes definitely.
When ergotamine is given subcutaneously in a dose of 5 mgrms. per kilo it does not essentially effect the blood sugar content of rabbits, normal and doubly splanchnicotomized as well, but given before pilocarpine, it acts to reduce the hyperglycaemic effect of pilocarpine.
