Abstract
Anaphylaxis was induced in the dogs, whose suprarenal medullae were previously removed, with simultaneous intravenous infusion of adrenaline hydrochloride solution at the rate with which the epinephrine was liberated from the suprarenals during anaphylaxis.
The blood sugar concentration increased, but its magnitude never corresponded to the sum of the increase due to the anaphylaxis alone and that due to the adrenaline infusion alone, done in expactly the same manner, but also rather similar or a little smaller than that causable by the each.
The mean blood pressure fell, too, in the present investigation in the scale similar with the anaphylaxis in normal dogs, doubly splanchnicotomized or medullisuprarenalectomized, but the pressurerecovered rapidly and completely, while it was slow and incomplete when the anaphylaxis was induced in the dogs, whose epinephrine liberation had been affected either by interference with the splanchnic nerves or the suprarenal medullae.
