Abstract
If yakriton is injected every three days into b- and f-classed rabbits in the amount of _??_ R. A. U. per kilo of body weight, and such an injection is repeated 5 times in succession:
(1) The total white cell count will show a comparatively marked increase in the third and the 5th hour after each injection. During the entire course of the 5 injection periods, taken as a whole, the number of leucocytes will show an inclination to decrease in b-classed animals, and to increase in f-classed ones.
(2) Lymphatic leucocytes will decrease in number after each injection, attaining the maximum (of decrease) in the 3rd or the 5th hour, though they will show almost no change in the absolute number. During the entire course of the 5 injection periods taken us a whole, they will show a normal number in b-classed animals, while in f-classed ones, a relative, as well as an absolute, increase will be seen.
(3) Myeloid leucocytes will show a relative, and an absolute, increase in number after each injection, attaining the maximum in the 3rd or the 5th hour. During the entire course of the 5 injection periods as a whole, there will be no special change of their number in b-classed animals, while in f-classed ones a relative decrease of them will be seen.
(4) Nuclear shift to the left is seen after each injection, and reaches the maximum in the 3rd hour. It is due to an increase of cells with rod-shaped nucleus, and of those of Type II, and to a decrease of cells of Types IV and V. The number of cells of rod-shaped nucleus will become about twice as large as before the injection in the case of the 1st and 2nd injections, but subsequent to the 3rd injection the increase will not become so remarkable.
It is to be noted here that this shift is of a regenerative nature. During the entire course of the 5 injection periods taken as a whole, the shift will become less pronounced. On the whole, an increase of cells with rod-shaped necleus is more to be seen in f-classed animals than in b-classed ones.
