On the Significance of the Augmented Epinephrine Secretion on Haemorrhage upon the Hyperglycaemia and Hypotension Simultaneously Occurring

抄録

In the dogs whose operation field was previously de-afferented, the suprarenal glands were removed by the lumbar approach, neither anaesthesia nor fastening being resorted to. Bleeding of one third of the total blood quantity was carried out. In some cases adrenaline hydrochloride was introduced intravenously with the velocity with which epinephrine is liberated from the suprarenal glands on bleeding of the same amount in normal dogs, that is non-anaesthetized, non-fastened.
The mean arterial pressure fell more extensively in the dogs which were deprived of the suprarenals about one hundred minutes previously, as compared with the dogs with intact glands, but the blood sugar concentration, generally speaking increased in similar scale in both sets of experiments. Death occurred more frequently among the decapsulated dogs.
The adrenaline infusion carried out besides the bleeding acted to rescue the decapsulated animals from death. and reduce the magnitude of the hyperglycaemia, while the blood pressure fell in scale similar to the cases without accompanying the adrenaline infusion, but it progressed slowly.