A Measure to Alter the Glycaemic Effect of Histamine and Peptone

抄録

The present investigations were undertaken to reconcile dis-crepancy between the reports of Watanabe and Kaiwaon one side who were always able to find hyperglycaemia on applying peptone into dogs or rabbits, and that of Ohm i who always found hypogly-caemia in rabbits by histamine. There is a definite difference in the experimental conditions between them, viz: the velocity with which the drug was introduced intravenously; it was short in the former, much longer in the latter.
In the present investigation both drugs were applied to normal rabbits and in fact in three modi: (1) intravenously rapidly (histamine 0.4-0.5 mgrm. per kilo of body weight in 5-20 seconds, peptone “Witte” 0.1-0.7 grm. in 20-25 seconds), (2) intravenously slowly (the same doses of histamine in 1-1.5 minutes, peptone 1-5 minutes) and (3) relatively small amount (histamine: 1 or 2 mgrms. per kilo. pep-tone: 0.2-0.7 gym.) hypodermically.
When the drugs of a given amount are injected intravenously rapidly, the blood sugar concentration increases, and when given slow-ly it decreases. Hypodermical application of both drugs in relatively small amount causes also invariably hypoglycaemia.
Briefly recapitulated The amount of histamine or peptone suf, ficiently large as to cause hyperglycaemia without fail when rapidly given intravenously, elicites, on the contrary, hypoglycaemia if it be given in the same manner, but slowly. By “rapid injection” it is meant here 5-10-30 seconds and by “slow” say 1-5 minutes.
Subcutaneous administration of a small amount of both drugs acts also simply hypoglycaemic. Of course intermediate forms of varia-tions in the sugar content can be observed. Thus here is now given, an experimental condition demonstrating how one is in a position to see without fail the hypoglycaemic action of histamine, peptone, an important condition which has been seemingly neglected by several writers in this field of research.