抄録
Acidosis occurs in patients of anaemia where the blood count is below three millions. It is relieved when the anaemia improves. In patients of anaemia breathlessness is observed also when the number of erythrocytes are reduced below one million and when marked acidosis is demonstrable.
Acute haemorrhagic anaemia experimentally produced in rabbits is accompanied by acidosis which developes the more markedly and disappears the more slowly when the more blood has been drawn. Generally acidosis is relieved more quickly than anaemia.
Intravenous infusion of normal saline solution in the cases of acute haemorrhage has no immediate effect upon the changed blood alkalinity, but accelerates the amelioration of anaemia and acidosis. By infusion of gum acasia solution the acidosis is lessened though slightly, while the recovery from anaemia and acidosis is, on the contrary, retarded. Blood transfusion maintains normal blood alkalinity, but for not longer than twenty-four hours on account of the gradual destruction of the transfused blood cells.
In subacute haemorrhagic anaemia caused by repeated bleeding acidosis is demonstrated when the haemoglobin content is reduced below 40%. First is lowered the carbon dioxide content of plasma, later the value of equilibrium constant of the oxygen dissociation curve.
In progressive toxic anaemia due to the administration of phenylhydrazine marked acidosis developes, the oxygen dissociation curve having already descended in the early stage.
In each type of experimental anaemias the relation between the severity of the anaemia and that of acidosis is discussed.
