The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Experimental Studies on Intermediate Metabolism in the Kidney in Hypertension
Yoshihiko Umehara
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1956 Volume 63 Issue 2-3 Pages 265-276


In order to investigate the intermediate metabolism of water, proteins, carbohydrates and electrolytes, in the kidney in experimental hyper-tension, the contents of these substances in the renal venous blood were estimated and compared with those in the arterial blood in normal rabbits as well as in the rabbits made hypertensive by the method of Goldblatt. The comparison of the corresponding data taken from both kinds of animals revealed following facts.
1. The release of water from the circulating blood into the kidney tends to be somewhat decreased in hypertensive animals.
2. The discharge of proteins from the blood into the kidney is aug-mented in hypertension. This increment is mainly due to albumin; on the contrary, globulin, especially β- and γ-globulin are transferred in a large quantity from the kidney into the circulating blood.
3. The discharge of blood non-protein nitrogen into the kidney tends to be reduced in hypertensive animals.
4. In hypertensive animals, the release of blood sugar into the kidney is augmented, while that of lactic acid is decreased.
5. Of the electrolytes in blood, the release of Cl and Na into the kidney is below normal; in some cases Cl and Na are transferred, though a little, in the reverse direction so that their contents in the renal vein are increased over those in arterial blood. The transfer of K and Ca into the kidney is increased over normal.
6. The rise of pH during the intrarenal circulation tends to be slightly augmented in hypertensive cases.

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