The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Chemical Nature of Toxohormone (Nakahara)
Eighth Report. Toxohormone AP II1 and II' from Cancerous and Noncancerous Ascitic Fluids
Hajime MasamuneSigetosi KamiyamaSin-iti AbeShoichi AbeMituo HagaHirosi Kaketa
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1959 Volume 69 Issue 2-3 Pages 245-256


1. There have been isolated toxohormones AP II1 and II' which are globulins in the cancerous ascitic fluid of stomach cancer patients and noncancerous ascitic fluid of liver cirrhosis patients respectively and both precipitate at 40 to 60% ethanol and at 1.0-1.4M ammonium sulfate.
2. They were examined biologically, chemically and physically.
3. They are devoid of anemia-inducing potency.
4. The former protein is more strongly toxohormone active than the latter, while they differ from each other only regarding serine content and phenylalanine, leucine and isoleucine content as a whole and possibly also regarding electrophoretic mobility, in so far as was examined.

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