Chemical Nature of Toxohormone (Nakahara)

Eighth Report. Toxohormone AP II₁ and II' from Cancerous and Noncancerous Ascitic Fluids

Abstract

1. There have been isolated toxohormones AP II₁ and II' which are globulins in the cancerous ascitic fluid of stomach cancer patients and noncancerous ascitic fluid of liver cirrhosis patients respectively and both precipitate at 40 to 60% ethanol and at 1.0-1.4M ammonium sulfate.
2. They were examined biologically, chemically and physically.
3. They are devoid of anemia-inducing potency.
4. The former protein is more strongly toxohormone active than the latter, while they differ from each other only regarding serine content and phenylalanine, leucine and isoleucine content as a whole and possibly also regarding electrophoretic mobility, in so far as was examined.