Abstract
Niacinamide in large doses (approximately 200mg/kg i. v.) increased the cardiac output of normal cats and of those after the ligation of the anterior descending branch of the left coronary artery. Sodium nicotinate in large doses (170mg/kg i. v.) had the same tendency, but less remarkable. These effects were compared with those of amyl nitrite and nitroglycerine in doses of 0.86-1.39mm3/kg and 0.32-0.52mg/kg i. v. respectively, which had ambiguous effects on the cardiac ouptut in both groups of cats. The effects of these drugs on the ECG findings are also briefly described.
This work was aided by grants (1959) from the National Council on Science Development of Republic of China. The author also would like to thank Dean H. Y. Wei for lending the ECG and to Prof. Y. Hosoya for his encouragement.
