The Observation on the Electron-microscopic Pictures of Cancer Cells Under The Actions of Chemotherapeutic Agents

Abstract

1) In the present paper were studied changes in fine structure of Yoshida's ascites sarcoma cells as well as Ehrlich's ascites hepatoma cells by several anticancer remedies: Citral, Nitromin, Sarcomycin, Carcinophyllin, Chromomycin, Azan, PCMB, and Colchicine.
2) The localities of the points of attack upon tumor cells by these remedies are quite different. Nitromin causes changes unanimously of the fine structures of tumor cells. Azan and Sarcomycin come next to Nitromin in the order of effectiveness. Carcinophyllin and Chromomycin act moderately and they affect structures of cytoplasm rather than nucleus. Citral when acted mildly causes changes in nuclear membrane, nucleolus, chromatin substance in the nucleus. Change of endoplasmic reticulum is much more remarkable than that of mitochondria. PCMB damages mitochondria almost exclusively.
3) A potential co-operation of these two kinds of remedies, aldehydes and PCMB, is discussed.