Abstract
In order to ascertain a correlation of the juxtaglomerular apparatus, renin or angiotensin and aldosterone to the arterial pressure, a series of ten groups of experiment was performed by rabbits and rats. Hypertrophy of the zona glomerulosa of the adrenal cortex and an elevated plasma aldosterone level were observed in rabbits receiving angiotensin IT. In the rats with Goldblatt hypertension, a slight increase in the juxtaglomerular granulation index in the clamped kidney and a marked decrease in the untouched contralateral kidney were observed. No appreciable change was detected in the zona glomerulosa. It was suggested that renin and/or angiotensin are potent stimulants of aldosterone secretion, but there was no evidence that the renin-angiotensin-aldosterone system is essential to induce or maintain renal hypertension. And an increase in the potassium content of the aortic wall in the rats with experimental hyperten-sion of Goldblatt and DOCA plus NaCl treatment seems to have a close relation to the development of hypertension.
