Abstract
Although the concept of ulcer-carcinoma of the stomach, i.e., carcinoma arising from a pre-existing gastric ulcer, seems to have received significant support, it is still a matter in considerable dispute among pathologists and surgeons. The authors reviewed a total of 2, 484 surgical specimens of the stomach which had been resected in the Tohoku University Hospital, and found probable evidence of early ulcer-carcinoma in 25 of them. These cases had typical chronic ulcer of the stomach and additional foci of early carcinoma-a single (two cases) or multiple (11 cases) small cancer foci in the mucosa of the ulcer margin, or a ring-shaped mucosal carcinoma involving the circumference of the ulcer (12 cases). The minute investigation of these early cases will greatly serve for the solution to the dispute mentioned above. This paper describes the histopathologic findings of these lesions and preoperative histories of the cases, and presents the authors' view in support of malignant change of gastric ulcer.
