Uracil-uric Refractory Anemia with Peroxidase Negative Neutrophils

Abstract

A peculiar disorder of a 7 year-4 month -old girl is described which is charac-terized by 1) a refractory hypochromic anemia with megaloblastic bone marrow of a slight degree, 2) an occurrence of the neutrophils which are negative to all the stains for peroxidase, oxidase, Sudan-black B and succinic dehydrogenase, 3) a urinary output of uracil, UMP and UDP, and 4) fatal outcome due to sepsis with leukemoid blood picture. A term “Uracil-uric Refractory Anemia with Peroxidase Negative Neutrophils” is suggested for this new disorder.