Effects of Atropine, Eserine and Tetramethylammonium on the Adrenal 17-Hydroxycorticosteroid Secretion in Anesthetized Dogs

Abstract

Effects of atropine, eserine and tetramethylammonium (TMA) on the adrenal 17-hydroxycorticosteroid (17-OHCS) secretion in dogs anesthetized with sodium pentobarbital were directly evaluated. Atropine, eserine or TMA was administered intravenously. Eserine (0.3mg/kg of body-wt.) produced a marked increase in 17-OHCS secretion and the maximal secretion rate was mostly observed at 10min after injection. TMA (1.0mg/kg) induced also a definite increase in adrenal 17-OHCS secretion, the maximal secretion rate being observed at 5 or 10min after administration. Atropine (1.0mg/kg) which had been proved to produce a marked increase in 17-OHCS secretion in conscious dogs had no effects on the secretion of 17-OHCS in dogs anesthetized with sodium pentobarbital.