Abstract
Plasma lactate in tumor-bearing rats increased progressively after inoculation with tumor cells. Plasma lactic dehydrogenase (LDH) activities were found increased in tumor-bearing rats, especially in cases of liver metastasis. The similarity between the LDH isozyme patterns of the plasma in tumor-bearing rats and those of the ascites tumor cells suggested that the tumor cells contributed greatly to the increase in plasma LDH of these animals. Michaelis constants for pyruvate of rat tissues and ascites tumor cells were closely related to the iso-zyme patterns.
