The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
Studies on Anti-diabetic Effect of Sodium Oxalcacetate
Kiyohiko Yoshikawa
Author information

Volume 96 (1968) Issue 2 Pages 127-141

Download PDF (2518K) Contact us

Many attempts have been made to treat diabetes mellitus with oral medication, but none of them seems to have been successful. It has been known that a decoction of Eunymus alata sieb growing in Japan has a blood sugar lowering action. The effective component was isolated, crystallized, and identified as oxaloacetic acid (OAA) by infrared spectral analysis. Stable salt of OAA (OAA-sodium) was prepared. The administration of OAA-sodium brought about lowering of the blood sugar level in normal and alloxan diabetic animals. The same drug was given to diabetic patients, and it was found effective in all of 10 of Type I and in 6 of 11 of Type II diabetics according to Yamakawa and Kurokawa's classifica-tion.
A long-term administration of OAA-sodium induced hyperplasia and proliferation of the islet cells of the pancreas in rats, but no mentionable changes were found in the other organs.
It is strongly suspected that OAA-sodium stimulates insulin secretion through some unknown mechanism.

Information related to the author
© Tohoku University Medical Press
Previous article Next article

Recently visited articles
  • About this Journal
    The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology.

  • Submitted manuscripts will be screened for plagiarism with Similarity Check (
Journal news & Announcements
  • Subscriptions
    Inland subscriptions should be sent to Tohoku University Medical Press, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, JAPAN.

    Subscriptions from abroad should be addressed to MARUZEN CO., LTD., EXPORT DEPARTMENT, Postal address: P.O.Box 75, Shinagawa, Tokyo 140-8799, JAPAN.