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Volume 96 (1968)
- Issue 4 Pages 313-
- Issue 3 Pages 211-
- Issue 2 Pages 113-
- Issue 1 Pages 1-
Volume 96, Issue 2
Displaying 1-13 of 13 articles from this issue
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Toshikatsu Seki, Keishi Abe, Toraichi Mouri, Masao Suzuki, Yukio Miura ...1968 Volume 96 Issue 2 Pages 113-118
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAn assay method for the level of kallikreinogen in human plasma was described: human plasma was incubated with trypsin at 37°C for 10 minutes, then egg white trypsin inhibitor was added to the incubation mixture to inactivate trypsin, and kallikrein thus produced was estimated by its depressor effect on the rabbit blood pressure.
The present investigation revealed that the plasma kallikreinogen levels in healthy persons ranged from 3.5 to 4.4 Frey units per ml of plasma. Low kalli-kreinogen levels were observed in some patients with hyperthyroidism or hepatitis. In some patients with bronchial asthma or Buerger's disease, rather high levels were, found.View full abstractDownload PDF (1732K) -
Eizo Yamashita, Nicholus Buendia1968 Volume 96 Issue 2 Pages 119-126
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAfferent impulses coming from the Pacinian corpuscles in response to mesenteric arterial pulsation were observed at the peripheral cut end of the cat's mesenteric nerves. The correlation between blood pressure and impulse frequency was not always fixed. There seemed to be differences in the behavior of the corpuscles. In some of them, the impulse frequency was increased by a rise in blood pressure, whereas in others it was depressed by blood pressure elevation. The result was explained from the observation that the mesenteric arteries were dislocated in such a way with their increased constriction that they drew toward or withdrew from the Pacinian corpuscles. Possible reflex for controlling abdominal functions was discussed with relation to vascular change.View full abstractDownload PDF (2327K) -
Kiyohiko Yoshikawa1968 Volume 96 Issue 2 Pages 127-141
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSMany attempts have been made to treat diabetes mellitus with oral medication, but none of them seems to have been successful. It has been known that a decoction of Eunymus alata sieb growing in Japan has a blood sugar lowering action. The effective component was isolated, crystallized, and identified as oxaloacetic acid (OAA) by infrared spectral analysis. Stable salt of OAA (OAA-sodium) was prepared. The administration of OAA-sodium brought about lowering of the blood sugar level in normal and alloxan diabetic animals. The same drug was given to diabetic patients, and it was found effective in all of 10 of Type I and in 6 of 11 of Type II diabetics according to Yamakawa and Kurokawa's classifica-tion.
A long-term administration of OAA-sodium induced hyperplasia and proliferation of the islet cells of the pancreas in rats, but no mentionable changes were found in the other organs.
It is strongly suspected that OAA-sodium stimulates insulin secretion through some unknown mechanism.View full abstractDownload PDF (2518K) -
Eiji Sekino, Sohei Suzuki, Susumu Ainai, Toshio Tsuge, Takeshi Momokaw ...1968 Volume 96 Issue 2 Pages 143-150
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSOptimum conditions for coronary flow under hypothermia were experimentally investigated on dogs. The control of coronary perfusion by flow rate alone was occasionally accompanied by undesirable side-effects, and adequate perfusion pressure was found to be important in sustaining optimum coronary flow. The most favorable results were obtained at perfusion pressures of 90mmHg at 30&C, 50mmHg at 25°C and 40mmHg at 20°C.View full abstractDownload PDF (1374K) -
Kiyota Oh-Uti, Kazuo Shindo, Toshizo Numata1968 Volume 96 Issue 2 Pages 151-159
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAnemia-inducing substances were extracted from gastric juice of patients with gastric cancer and from human placenta. The immunological relationship of these substances was tested by the gel diffusion technique of Ouchterlony.
The results were summarized as follows:
1) A rabbit was immunized with an anemia-inducing substance from the placenta (P-62) using Freund's adjuvant. The antiserum prepared was tested for the presence of antibodies against P-62 by complement fixation test. The test showed a high titer of 1:512. The antiserum was designated as P-62•Ab.
2) Analyses by Ouchterlony's method showed that P-62•Ab reacted markedly with P-62 and with an anemia-inducing substance from gastric juice (K-8) of patients with gastric cancer. But the corresponding fraction from normal gastric juice did not show the reaction with P-62•Ab.
3) These results indicated that there was a common antigenicity between anemia-inducing substances in the cancerous gastric juice (K-8) and in the human placenta (P-62).View full abstractDownload PDF (2168K) -
Keigo Yasuda, Susumu Satoh, Norio Taira, Koroku Hashimoto1968 Volume 96 Issue 2 Pages 161-164
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIt was demonstrated in both in vivo and in vitro experiments on the renal circulation that dipyridamole produced the potentiation of vascular responses not only to adenosine but also to norepinephrine. The potentiation of these responses was observed when concentrations of dipyridamole were relatively low. As the concentration of dipyridamole was elevated, the potentiation was rather decreased and finally abolished. Furthermore, in in vitro experiments, higher concentrations of dipyridamole blocked the action of norepinephrine. These results cast doubt on the mode of dipyridamole action, which has been interpreted as inhibition of deamination of adenosine.View full abstractDownload PDF (222K) -
Takashi Miura1968 Volume 96 Issue 2 Pages 165-170
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe indirect fluorescent antibody technic was applied clinically to detection of an antibody or antibodies in the sera of patients with or without dermatophyte infection. By this technic the antibody or antibodies could be found at a high rate in the sera of patients with dermatophyte infection. But strong cross-reactions were observed between the sera and non-causative fungi, and no direct relationship was found between the intensity of the reaction and that of the infection. Clinical application of the method, therefore, is still open to research. Such antibodies were also found in the sera of not a few patients without the infection, but they could not be found in the sera of all the examined children. Subclinical but anti-body-stimulating infection of dermatophytes may be considered to play a role in the antibody formation.View full abstractDownload PDF (805K) -
Tokio Onodera, Masahiro Onuma, Gentaro Miura, Morio Kasai1968 Volume 96 Issue 2 Pages 171-180
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSeventy-four patients of acute diffuse peritonitis were briefly reviewed. Fecal peritonitis due to perforation of the colon showed a remarkably high mortality, though the operation was carried out in general earlier than in other types of peritonitis.
Three types of peritonitis, fecal, gastric juice and bile peritonitis, were produced experimentally in dogs. Changes in blood pressure, hematocrit, plasma protein, plasma volume, water contents of the intestine, acid-base balance and bacterial culture of the blood were studied in each type of peritonitis.
Severe hypovolemia was considered to be an important factor in the early development of shock in fecal peritonitis, but hypovolemia alone was not sufficient to account for the extreme severity of fecal peritonitis.
Blood culture became positive within a few hours after the onset of fecal peritonitis and severe septicemia, seemed to be another important factor which contributed to aggravation of symptoms in this disease. The present authors, however, could not demonstrate endotoxin-like substance in the circulating blood of dogs with severe fecal peritonitis.View full abstractDownload PDF (516K) -
Tokio Onodera, Masahiro Onuma, Yoshiyuki Okada, Shigeru Matsuoka, Mori ...1968 Volume 96 Issue 2 Pages 181-189
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn a previous report, rapid development of by povolemia, severe metabolic acidosis and bacteremia of gram-negative bacilli were demonstrated in dogs with experimental fecal peritonitis. Therefore, the effect of fluid administration was examined. In gastric juice peritonitis, the experimental animals recovered from shock only after fluid administration even in the late stage. In the fecal peritonitis, however, fluid therapy was far less effective. Although intravenous instillation of a large amount of fluid, which was started immediately after intraperitoneal injection of fecal material, maintained systemic blood pressure at normal level for a con-siderable period and prolonged the survival time, it was not effective in preventing elevation of hematocrit and severe metabolic acidosis. On the other hand, rapid administration of a large amount of fluid in cases of already advanced fecal peri-tonitis showed only transient improvement of systemic blood pressure and could not improve metabolic acidosis, nor caused it any significant prolongation of survial of the animals. The effect of intraperitoneal administration of antibiotics was evaluated in the fecal peritonitis. Even large doses of antibiotics could not prolong the survival time of experimental animals when an extremely large amount of fecal material had been injected intraperitoneally. The treatment was effective only when intraperitoneal contamination was not so severe.View full abstractDownload PDF (445K) -
Yoshimasa Yokoyama, Keiya Tada, Toshio Yoshida, Hiroshi Nakagawa, Tsun ...1968 Volume 96 Issue 2 Pages 191-198
Published: 1968
Released on J-STAGE: November 17, 2010
JOURNAL FREE ACCESSPaper chromatographic examination on urinary tryptophan metabolites following an oral dose of L-tryptophan, 100mg/kg, was carried out on infants and children with convulsive disorders including infantile spasm.
The incidence in cases with abnormal tryptophan metabolism was found to be higher in cases with convulsion than in those without convulsion.
A detailed study on an infant with typical infantile spasm revealed that there was a marked increase in urinary excretion of kynurenine, kynurenic acid and xanthurenic acid following the oral dose of tryptophan, and that the glutamic oxaloacetic transaminase activity of erythrocytes, vitamin B6 levels of serum, and the kynureninase activity of the liver were within normal limits. From the present finding it was assumed that the abnormality in tryptophan metabolism observed in some cases with convulsive disorders might not be a cause of convulsion, but a sequential phenomenon associated with convulsion.View full abstractDownload PDF (802K) -
Yoshimasa Yokoyama, Keiya Tada, Tsuneo Arakawa1968 Volume 96 Issue 2 Pages 199-206
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSXanthurenic aciduria following an oral dose of tryptophan was frequently seen in children with convulsive disorders. In order to elucidate the mechanism through which xanthurenic aciduria developed in these children, a study of liver enzymes related to tryptophan metabolism was done on rats with electric convul-sions.
The results showed that, in rats with the electric convulsion, there was a marked elevation of tryptophan pyrrolase activity but no remarkable change in activities of both kynureninase and kynurenine transaminase of the liver and an increase in urinary excretion of xanthurenic acid following an oral dose of tryptophan.
From these results, it was suggested that xanthurenic aciduria in children with convulsive disorders was due to an enhanced yielding of xanthurenic acid as a result of increased activity of try ptophan pyrrolase induced by convulsions.View full abstractDownload PDF (392K) -
Koroku Hashimoto, Nobuyuki Sano1968 Volume 96 Issue 2 Pages 207-208
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDownload PDF (100K) -
Norio Taira, Satoshi Matsumura, Koroku Hashimoto1968 Volume 96 Issue 2 Pages 209-210
Published: 1968
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA muscarinic ganglionic stimulant, 4-(m-chlorophenyl-carbamoyloxy)-2-butynyltrimethylammonium chloride (McN-A-343) administered into the perfused canine caudal vesical arteries caused a contraction of the bladder resembling that elicited by acetyylcholine. The contraction produced by MeN-A-343 was abolished by tetrodotoxin as that induced by a nicotinic ganglionic stimulant, 1, 1-dimethyl-4-phenylpiperazinium iodide (DMPP). However, unlike the response to DMPP, the response to McN-A-343 was abolished by atropine as readily as that to acetylcholine. These results indicate that the parasympathetic ganglia in the bladder wall have muscarinic sites distinct from those activated by nicotinic compounds as do sympathetic ganglia elsewhere.View full abstractDownload PDF (120K)
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