Abstract
Anemia-inducing substances were extracted from gastric juice of patients with gastric cancer and from human placenta. The immunological relationship of these substances was tested by the gel diffusion technique of Ouchterlony.
The results were summarized as follows:
1) A rabbit was immunized with an anemia-inducing substance from the placenta (P-62) using Freund's adjuvant. The antiserum prepared was tested for the presence of antibodies against P-62 by complement fixation test. The test showed a high titer of 1:512. The antiserum was designated as P-62•Ab.
2) Analyses by Ouchterlony's method showed that P-62•Ab reacted markedly with P-62 and with an anemia-inducing substance from gastric juice (K-8) of patients with gastric cancer. But the corresponding fraction from normal gastric juice did not show the reaction with P-62•Ab.
3) These results indicated that there was a common antigenicity between anemia-inducing substances in the cancerous gastric juice (K-8) and in the human placenta (P-62).
