抄録
The fine structural localization of acid phosphatase activity in myeloma cells was determined in four cases of multiple myeloma. The four patients consisted of two with IgG myeloma, one with IgA myeloma and one with Bence-Jones protein myeloma.
Light microscopic histochemistry using the azo dye method revealed intense acid phosphatase activity in all myeloma cells. Moreover, electronmicro-scopic histochemistry using the metal salt method demonstrated definite locali-zation of acid phosphatase activity in the cell. It was mainly observed in close association with granular endoplasmic reticulum as well as dense bodies and Golgi area. The acid phosphatase activity in granular endoplasmic reticulum may suggest some relationships between acid phosphatasc activity and immunoglobulin production in myeloma cells.