抄録
Two groups of patients who were well controlled with insulin or with sulfonylurea were selected retrospectively, and their clinical and laboratory findings were analysed to compose discriminant function with the best separation.
Age of onset, duration of diabetes mellitus, obesity index, fasting blood sugar level, urinary sugar for twenty-four hours, serum total cholesterol level, systolic and diastolic blood pressure, PSP (15 min.), and retinal findings before treatment were adopted for the study.
The composed discriminant function formula was
Y=-0.484×age of onset +0.176×duration of diabetes
-0.454×obesity index +0.586×fasting blood sugar
-0.047×urine sugar +0.066×cholesterol
+0.173×systolic blood pressure -0.037×diastolic blood pressure
-0.160×retinal findings +0.191×PSP
Data for each variable were standardized before used in the formula.
Negative score with this linear function suggest an indication for the treatment with sulfonylurea, and positive score with insulin.
The four most effective variables were used for the simplified discriminant function for the clinical usage as followings;
Y=-0.394×age of onset -0, 471×obesity index
+0.684×fasting blood sugar +0.005×urine sugar
Predata processings for diabetic patients complicated with nephropathy and/or liver cirrhosis are under study for the application of discriminant function.
