抄録
Relaxant effects of a potassium channel opener (PCO) on contraction induced by norepinephrine and interactions of PCO and sulfonylureas in aortas from control and diabetic rats were investigated. Relaxant effects of PCO on norepinephrine induced contraction were attenuated in diabetic rats as compared with those in control rats, suggesting an abnormality of potassium channels in diabetes. With sulfonylurea pretreatment, the contraction-response curves for the relaxant effects of PCO were significantly attenuated and also shifted to the right in diabetic rats as compared with those in control rats. Tolbutamide exerted an effect in a concentration range similar to the therapeutic range, suggesting the possibility of an interaction between tolbutamide and PCO in clinical usage.
