Journal of Toxicologic Pathology
Online ISSN : 1881-915X
Print ISSN : 0914-9198
ISSN-L : 0914-9198

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Spontaneous Nephroblastoma with Lung Metastasis in a Rat
Yuko ITOKohei MATSUSHITATakuma TSUCHIYAYukari KOHARATsuyoshi YOSHIKAWAMakoto SATOKeisuke KITAURASatoshi MATSUMOTO
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ジャーナル フリー 早期公開

論文ID: 2013-0059

この記事には本公開記事があります。
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This report describes a spontaneous nephroblastoma with lung metastasis in a 10-week-old male Crl:CD(SD) rat. Macroscopically, a white mass in the kidney and two white masses in the lung were observed. Histopathologically, the renal mass was located in the cortex of a kidney, and it caused pressure on the surrounding renal parenchyma. Three components could be distinguished in the tumor: blastemal, epithelial (primitive glomerular/tubular structures) and mesenchymal (neoplastic connective tissues) elements. Immunohistochemically, the tumor cells were positive for Wilms tumor 1 protein (WT1) and vimentin. Metastasis was found in the lung. Thus, the case was diagnosed as a nephroblastoma with lung metastasis.
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© 2014 The Japanese Society of Toxicologic Pathology
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