エピゲノム制御の可塑性

抄録

The eukaryotic genome is divided into two domains: euchromatin and heterochromatin. Furthermore, heterochromatin is broadly classified into two types, constitutive and facultative heterochromatin, which are epigenetically regulated by the H3K9 methylation and H3K27 methylation (Polycomb repressive complex：PRC) regulatory systems, respectively and separately. Interestingly, these two heterochromatin states are maintained by the other regulatory system to some extent from each other if the respective responsible epigenomic machinery fails to work.

Recently, various epigenome changes and plasticity have been observed in response to environmental stimuli during developmental stages and long-term life activities including aging, suggesting that these epigenome changes are associated with pathological or physiological biological dysfunction.

In this context, I would like to discuss with participants how the heterochromatin-regulated plasticity we are finding contributes to human health and disease.