抄録
There are two different views on the absorption of thiamine from intestinal tract. One of them is a physical absorption theory based on diffusion, etc. and another a phosphorylation theory. The investigation on the effect of bile on thiamine indicated that there was a significant difference in the disappearance of thiochrome reaction of the vitamin added to bile between normal bile and that of hepatic disease. Bile seems to be participated in the absorption of thiamine from intestinal tract, since the rate of decreasing thiochrome reaction with normal bile was higher than that of hepatic disease. Comparative estimation of total and free thiamine of portal blood, liver, and peripheral blood was made after injection into duodenum of the vitamin with normal bile and with that of hepatic disense. The result indicated that in case of bile of hepatic disease free thiamine increased in portal blood, but remained constant in peripheral blood, while in case of normal bile combined form of the vitamin in portal blood. These findings suggest that thiamine might be absorbed as a phosphorylated form. Furthermore, experiment on the urinary excretion of the vitamin and the content in the liver showed that the absorption of the vitamin was inferior in dogs with hepatic disease. When thiamine was orally administered to patientts with protal hypertension, the vitamin in peripheral blood did not so much increase, while when the vitamin was parenterally given and liver protecting treatment was performed, total and combined form of the vitamin did not so much increase in patients with severe hepatic disease, but the combined form of the vitamin increased to some extent in patients with light hepatic disease. Pareuteral administration of thiamine and simultaneous liver protecting treatment seem to be necessary for patients with hepatic disease.
