神経組織におけるビタミンB_1の分布に関する実験的研究 : (II)ビタミンB_1およびTHIAMINEPROPYLDISULFIDE負荷時における血液ならびに神経組織中ビタミンB_1含有量の消長

抄録

White male rabbits were divided into 2 groups, and injected with thiamine or thiaminepropyldisulfide, 2 mg per kilogram respectively. Then the thiamine contents in the blood and the neural tissues were measured following the course of time. Immediately after the intravenous injection, thiamine contents in the blood showed the maximum value and it diminished with the lapse of time thereafter. Generally, the rate of increase of thiamine contents in the neural tissues after the administration was slower than that in the blood. Thiaminepropyldisulfide had a stronger power of increasing thiamine contents in the blood and the neural tissues than thiamine, and the maintenance of high concentration was apparently more pronounced also.