ANTAGONISM BETWEEN THIAMINE AND SULFA DRUGS IN MICROBES : (II) ANTAGONISM BETWEEN THIAMINE AND IT'S STRUCTURAL ANALOGUES

Abstract

The effect of thiamine on the therapeutic action of sulfadiazine and sulfathiazole was compared with that of p-aminobenzoic acid in mice. In mice innoculated with Bacillus anthracis thiamine and p-aminobenzoic acid reduced the therapeutic effects of sulfadiazine and sulfathiazole, but the effect was far less in thiamine than in p-aminobenzoic acid. In mice not innoculated with the Bacillus, thiamine and p-aminobenzoic acid reduced markedly the lethal dosis of the sulfa drugs.