Abstract
The author measured the respiration of microbes under the presence of two kinds of drugs, which antagonize one to another by their structural resemblance, for instance, thiamine and sulfathiazole or sulfadiazine, by the method of Cartesian-Diver's microrespirometer. On the growth and the respiration of microbes, the effect of thiamine antagonized that of sulfadiazine and sulfathiazole, but more pronouncedly that of PABA. Among the thiamine homologues, thiamine-propyl- and allyldisulfide alleviated the suppression of respiration by sulfa drugs at early stage. These results seem to suggest that thiamine homologues pass more repidly through the membrane than thiamine.
