抄録
The action of 2-methyl-4-amino-5-hydroxymethylpyrimidine on the brain enzyme system, that is, glutamic decarboxylasse, γ-aminobutyric-α-ketoglutaric transaminase and the coenzyme supplying system, pyridoxal-kinase, was studied in vitro. Brain glutamic decarboxylase is not inhibited by 2-methyl-4-amino-5-hydroxymethylpyrimidine in its original form but is inhibited by the phosphorylated form. The γ-aminobutyric-α-ketoglutaric transaminase, however, is not affected by either form. It was also found that 2-methyl-4-amino-5-hydroxymethylpyrimidine inhibits the phosphorylation of pyridoxal.
