抄録
Intravenous administration of lysine caused decreased urinary excretion of biotin in some patients with liver diseases, diabetes mellitus and polyneuritis. Increase of urinary biotin after biotin loading, was less in these patients when lysine was administered previously. Biotin administration caused increase in hepatic content of bound biotin in normal rat. Less marked increase was found in rats with acute CCl_4 poisoning or alloxan diabetes. Simultaneous administration of lysine caused more marked increase in hepatic content of bound biotin in normal rats. The similar effect of lysine was not demonstrated in rats with CCl_4 poisoning or alloxan diabetes. The biosynthesis of bound biotin seemed to be disturbed in these conditions.
