抄録
In order to study the effect of vitamin B_6 deficiency on the cardiovascular lesions and serum cholesterol level, histological and biochemical experiments were made on 78 rats fed on a normal or an atherogenic diet for 13-26 weeks. In rats fed on a vitamin B_6 deficient diet for 22 or 26 weeks degenerative changes of heart muscle were observed. In the media of arteries of the vitamin B_6 deficient rats degenerative changes of the elastic and muscular fibers and accumulation of metachromatic material were observed, while in the initima plaques of fibrous tissue, atherosclerotic lesions, splitting and duplication of the internal elastic lamina, and the blister-like separation of the endothelium occurred. The vitamin B_6 deficient rats showed a higher serum choresterol level than the control.
