巻号一覧
19 巻
選択された号の論文の322件中1～50を表示しています
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Paul GYORGY, 勝井 五一郎原稿種別: 本文
1960 年 19 巻 p. 1-7
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 19 巻 p. 7-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 19 巻 p. 7-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 19 巻 p. 7-
発行日: 1960年
公開日: 2017/12/22
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上久保原稿種別: 本文
1960 年 19 巻 p. 7-
発行日: 1960年
公開日: 2017/12/22
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伊藤 真次, 久米 敏夫原稿種別: 本文
1960 年 19 巻 p. 8-10
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーTo know the effect of γ-aminobutyric acid and β-hydroxy-γ-aminobutyric acid, which have been presumed to be chemical transmitters of inhibitory impulses in the brain, on the pituitary-adrenal activity, these compounds were injected intraperitoneally into rats. Marked depletion in adrenal ascorbic acid content was observed in intact rats, but no change in hypophysectomized ones. γ-Aminobutyric acid administration also caused an increase in urinary excretion of 17-ketosteroids. These results indicate that γ-aminobutyric acid and β-hydroxy-γ-aminobutyric acid act as stress agents.抄録全体を表示PDF形式でダウンロード (335K) -
清水原稿種別: 本文
1960 年 19 巻 p. 10-
発行日: 1960年
公開日: 2017/12/22
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荒川 雅男原稿種別: 本文
1960 年 19 巻 p. 11-22
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーRiboflavin deficiency has been of endemic occurrence in Miyoshi village, a farm district in Aomori Prefecture, where peat deposits were distributed widely and found superficially beneath the earth. The well-water in this area showed higher content in Mg, Mn, Na, Ca, Cl and phenol than city-water. The present work was attempted to investigate the influence of well-water upon riboflavin metabolism of rats. After feeding on standard diet prepared by using city-water, the rats were divided into 3 groups, according to the kind of water which was used for preparing food and for drinking. Group 1 (city-water group), group 2 (well water group) and group 3 ("Mn-water" group). "Mn-water" was the city water into which MnCl_2 was added in the same concentration as contained in the well-water, amounting to 10 ppm Mn. Each of water was given in an amount of 20ml per day per rat. In groups 2 and 3 as compared with group 1,marked decrease in riboflavin concentration was found in blood, liver and kidney, which were examined on the 6th month after giving well-water or Mn-water. Urinary output of riboflavin was increased temporarily over a period from 10 to 20 days after giving well-water or "Mn-water", and thereafter it decreased gradually, simultaneonsly with the decrease of riboflavin in stools. These results was explained by the experimental findings that well-water, especially Mn^<++> in it, activated nucleotide pyrophosphatase (FAD-FMN) and drived out riboflavin from the body into urine on one hand, and depressed intestinal synthesis of riboflavin on the other hand.抄録全体を表示PDF形式でダウンロード (1075K) -
清水原稿種別: 本文
1960 年 19 巻 p. 22-
発行日: 1960年
公開日: 2017/12/22
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長野 登紀子原稿種別: 本文
1960 年 19 巻 p. 23-33
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーBlood ascorbic acid content was in normal range in patients with rheumatic fever, but was low in rheumatoid arthritis. However in the acute phase of rheumatic fever, increase of the content was observed, while it was remarkably low in active stage of rheumatoid arthritis. Aspirin treatment caused a decrease of blood ascorbic acid level in every case. Urinary excretion ratio of ascorbic acid after intravenous administration of 100mg of ascorbic acid was remarkably low in rheumatic diseases. However, the ratio increased to the normal value in parallel with improvement of acute symptoms. Blood ascorbic acid level showed positive correlation with serum mucoprotein level and urinary excretion of 17-ketosteroid in rheumatic fever, while negative correlation was observed in rheumatoid arthritis. Ascorbic acid administration restained the increase of urinary excretion of 17-ketosteroid caused by steroid treatment, while in two female patients such an effect of ascorbic acid was not observed.抄録全体を表示PDF形式でダウンロード (1179K) -
勝井 五一郎, 三枝 礼子原稿種別: 本文
1960 年 19 巻 p. 33-37
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーVitamin A aldehyde was obtained as yellow crystals from MnO_2 treated natural vitamin A concentrates. From the reaction with maleic anhydride and an infra-red spectrum, it is reasonable to believe that the crystals would have all-trans configuration. Various other properties are well agreed with those reported by others. The stability of the aldehyde against oxidation was rather higher than the stabilities of vitamin A alcohol and vitamin A acetate. A color formed by the addition of SbCl_3 reagent was also found to be more stable than with the two latter.抄録全体を表示PDF形式でダウンロード (470K) -
清水原稿種別: 本文
1960 年 19 巻 p. 37-
発行日: 1960年
公開日: 2017/12/22
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堀尾 昭原稿種別: 本文
1960 年 19 巻 p. 38-47
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThe intestinal amines of biological origin were experimentally proved to have toxicity for the liver, and when some disorders had occurred in the process of transaction of the amines in vivo, the toxicity increased. The author assumed that such liver disorders possibly occurred based on metabolic disturbances of a certain vitamin B-complex (thiamine, riboflavin, nicotinic acid, vitamin B_6,choline, etc.), particularly vitamin B_6. Concerning histamine, it has been reported that coenzyme of oxidizing enzyme of histamine is vitamin B_6 or riboflavin. According to our previous experiment, it seemed to be very possibile that vitamin B_6 might be coenzyme of histaminase, and investigations on the influence of amines of biological origin, especially of histamine, on the deficiency of vitamin B_6 were performed.抄録全体を表示PDF形式でダウンロード (1602K) -
桂原稿種別: 本文
1960 年 19 巻 p. 47-
発行日: 1960年
公開日: 2017/12/22
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桂原稿種別: 本文
1960 年 19 巻 p. 47-
発行日: 1960年
公開日: 2017/12/22
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川崎 近太郎, 堀尾 嘉友原稿種別: 本文
1960 年 19 巻 p. 48-53
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThiamine, added to series of borate-KCl-NaOH buffers between pH 7 and 12.5,was determined as thiochrome by the following procedures : (a) immerdiately, (b) after standing for 1 hour at 30℃, and (c) after standing for 1 hour at 30℃ and then acidifying the solution by HCl, all using ferricyanide-NaOH or (d) after standing with ferricyanide for 1 hour at 3O℃, then adding NaOH to it. The formation of thiochrome was observed as (a) 100% all over the ranges, (b) sharp decrease between pH 9 and 10,then 0% beyond pH 10.5,(c) the least yield at pH 9.6,while 100% at pH 7 or 12.5 and (d) gradual decrease between pH 8 and 11. The similar determination of thiamine using cyanogen bromide instead of ferricyanide was carried out by the procedures (a)〜(d) : The formation of thiochrome was shown to be similar in the cases of (b) and (c) but different in the cases of (a) and (d) which both indicated sharp decrease between pH 10 and 11 then 0% beyond pH 12. The decomposition of thiamine at pH 9.6 in (c) was proved to be its oxidation to thiamine disulfide which was recovered as thiamine by cysteine-treatment.抄録全体を表示PDF形式でダウンロード (579K) -
河内 耕也原稿種別: 本文
1960 年 19 巻 p. 54-60
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーIt is worthy to note that #1-19,a mutant strain of E.coli, responds to both of pantothenate moieties, β-alanine and pantoyl lactone. Metabolic accumulation of pantothenate precursors by pantothenate auxotrophs was studied, and the accumulation of β-alanine in pantoic-less culture and the pantoyl moiety in a β-alanine-less culture was demonstrated. Both of the two moieties were also demonstrated in a culture of preformed pantothenate requiring mutants. Neither of the moieties was, however, demonstrated in the cultures of #1-19 and of the parent strains.抄録全体を表示PDF形式でダウンロード (766K) -
脇坂 宣尚原稿種別: 本文
1960 年 19 巻 p. 61-64
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーVitamin B_<12> requiring Escherichia coli mutants #215 and #113-3 occasionally revert to the prototrophic state during the serial transfers in an ordinary nutrient medium. The rates of reverse mutation of these cultures were determined according to the method reported by Lea and Coulson. Percentage of the culture containing non-reverse mutant was estimated utilizing the modified synthetic medium of Johansson, supplemented by limiting amounts of vitamin B_<12>, and the rates were estimated as 0.18-0.08×10^<-9> in #215 and 2.4±0.11×10^<-9> in #113-3.抄録全体を表示PDF形式でダウンロード (496K) -
林 直行原稿種別: 本文
1960 年 19 巻 p. 64-75
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThe author investigated ceruloplasmin, one of blood enzymes, from the viewpoints of the enzyme activity and the activity as a metabolic factor of the heavy metals in central nervous diseases. At the same time, he observed the close relation with vitamin which was essential in the metabolism in vivo, especially with ascorbic acid which was directly connected with the redox action, and tried to clarify the significance of ascorbic acid in ceruloplasmin metabolism. Among various central nervous diseases, ceruloplasmin oxidase activity increased in the average in schizophrenic group compared with that in normal controls, but such tendency was observed in several other central diseases, and therfore was not specific to schizophrenics. As for ascorbic acid concentration, it decreased in schizophrenic group than in normal controls. Besides, there was correlation between the increase of the activity and the decrease of the concentration, and these were nearly parallel in normal controls too. There were also some other diseases in which the increase of the activity and the decrease of the concentration were observed, but no significant relation was found between them. Furthermore, in relation with these enzyme systems, the influence of hormone on the enzyme activities and the correlation between hormone and ascorbic acid concentrations were investigated.抄録全体を表示PDF形式でダウンロード (1522K) -
林 宏治原稿種別: 本文
1960 年 19 巻 p. 75-86
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーOrotic acid administered before the injection of carbon tetrachloride and ethionine to albino rats protected the central necrosis by the former, and the fat infiltration and glycogen diminution by the latter. Orotic acid administration following the injection of these toxic compounds also accelerated the repair of histological changes of damaged liver. These curative effects of orotic acid were increased by the use together with folic acid or vitamin B_<12>.抄録全体を表示PDF形式でダウンロード (1916K) -
高田原稿種別: 本文
1960 年 19 巻 p. 86-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 19 巻 p. 86-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 19 巻 p. 86-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 19 巻 p. 86-
発行日: 1960年
公開日: 2017/12/22
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勝又 増幸, 萩原 一成, 稲垣 延貞, 飯沼 康博, 榊原 栄一原稿種別: 本文
1960 年 19 巻 p. 87-91
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThe glutamate metabolism of Bacillus aneurinolyticus treated at a low temperature (about 3℃)was studied. Keeping the cells at the temperature caused decrease of the metabolic rate, especially the rate of glutamate or pyrrolidone carboxylate metabolism. And a parallel decrease of thiaminase II activity with that of the metabolic rate was also observed under such a condition. Studies were made on change of the metabolic rate of glutamate or other substrates at different growth phases, namely logarithmic phase and phases before and after the spore formation. The metabolic rate of glutamate or pyrrolidone carboxylate was found to change in parallel with thiaminase II activity, and the highest rate was observed in the resting cells before the spore formation. These results suggest that thiaminase II is concerned in the glutamate metabolism passing through pyrrolidone carboxylate.抄録全体を表示PDF形式でダウンロード (472K) -
瀬口 利一原稿種別: 本文
1960 年 19 巻 p. 91-95
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーFor the purpose of clarifying the role of thiaminase II of Bacillus aneurinolyticus, the enzymic activity of the bacterial cells was investigated. The activity was not affected by chelating agents and metallic ions except Cu^<++>, while increased by the addition of cysteine and the substrates relating to the respiration of the organism. The most remarkable effect was observed with cysteine and glutamate. These results suggest that the enzyme is concerned in the glutamate metabolism of this bacterium.抄録全体を表示PDF形式でダウンロード (571K) -
桂原稿種別: 本文
1960 年 19 巻 p. 95-
発行日: 1960年
公開日: 2017/12/22
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桂原稿種別: 本文
1960 年 19 巻 p. 95-
発行日: 1960年
公開日: 2017/12/22
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瀬口 利一原稿種別: 本文
1960 年 19 巻 p. 96-99
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThiaminase II formation in the synthetic medium without glycerine was compared with that in bouillon or glycerine containing synthetic medium. In the former medium the bacteria were obliged to utilize glutamate as the sole source or carbon. Glycerine, degrading through pyruvate in the cells, inhibited the enzyme formation. These results suggest that the enzyme controls the glutamate and α-keto acids metabolism of the organism.抄録全体を表示PDF形式でダウンロード (474K) -
勝又 増幸, 横田 真平, 瀬口 利一, 志野 義之, 飯沼 康博, 榊原 栄一原稿種別: 本文
1960 年 19 巻 p. 100-104
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーStudies were made in an aerobic condition on the respiratory metabolism of each component of the previously reported new synthetic medium for Bacillus thiaminolyticus. The results were as follows : It was clarified that glutamate was used as a chief energy source during the proliferation process, especially for the pellicle formation and enzyme production. Although glycerine was utilized more than glutamate as a substrate of the aerobic respiratory metabolism, the pellicle formation and enzyme production was strongly inhibited in the glycerine containing medium because of acidification of the medium. Furthermore, it was cleared that citrate was not only utilized for the stabilization of ferrous salt in the medium, but also for the spore formation.抄録全体を表示PDF形式でダウンロード (587K) -
桂原稿種別: 本文
1960 年 19 巻 p. 104-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 19 巻 p. 104-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 19 巻 p. 104-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 19 巻 p. 104-
発行日: 1960年
公開日: 2017/12/22
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宮沢 滋原稿種別: 本文
1960 年 19 巻 p. 105-109
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThe growth of Lactobacillus arabinosus 17-5 was investigated in several media containing D(-)-threo isomer (chloramphenicol), L(+)-threo isomer, L(+)-erythro isomer, and racemic threo isomer, respectively. All of these four isomers showed the stimulatory effect on its growth, L(+)-threo isomer being the most effective. Chioramphenicol at a concentration of 0.5 μg/cc inhibited its growth in the media containing other isomers.抄録全体を表示PDF形式でダウンロード (458K) -
桂原稿種別: 本文
1960 年 19 巻 p. 109-
発行日: 1960年
公開日: 2017/12/22
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宮沢 滋原稿種別: 本文
1960 年 19 巻 p. 110-112
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThe growth of Lactobacillus arabinosus 17-5 was investigated in several media containing allied compounds of chloramphenicol, 1-(p-nitrophenyl)-2-amino-1,3-propanediol (base), α-amino-β-hydroxy-p-nitropropiophenone (phenone type), and p-nitrobenzoic acid, respectively. All of them stimulated its growth, phenone type and p-nitrobenzoic acid being more effective. Chloramphenicol stimulated its growth in the medium without them, but inhibited its growth in the medium with them.抄録全体を表示PDF形式でダウンロード (354K) -
清水原稿種別: 本文
1960 年 19 巻 p. 112-
発行日: 1960年
公開日: 2017/12/22
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宮沢 滋原稿種別: 本文
1960 年 19 巻 p. 113-117
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThe pathway of decomposition of chloramphenicol into PABA by Lactobacillus arabinosus 17-5 was postulated from the results obtained by paper chromatography, and was proved from the results obtained by its growth test. This pathway differs from that postulated by Smith and Worrel, and is summarized as follows : Chloramphenicol→1-p-nitrophenyl-2-amino-1,3-propanediol→α-amino-β-hydroxy-p-nitropropiophenone→(p-nitrobenzoic acid)→p-aminobenzoic acid抄録全体を表示PDF形式でダウンロード (480K) -
山本 孝之原稿種別: 本文
1960 年 19 巻 p. 117-132
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーIn order to study the effect of vitamin B_6 deficiency on the cardiovascular lesions and serum cholesterol level, histological and biochemical experiments were made on 78 rats fed on a normal or an atherogenic diet for 13-26 weeks. In rats fed on a vitamin B_6 deficient diet for 22 or 26 weeks degenerative changes of heart muscle were observed. In the media of arteries of the vitamin B_6 deficient rats degenerative changes of the elastic and muscular fibers and accumulation of metachromatic material were observed, while in the initima plaques of fibrous tissue, atherosclerotic lesions, splitting and duplication of the internal elastic lamina, and the blister-like separation of the endothelium occurred. The vitamin B_6 deficient rats showed a higher serum choresterol level than the control.抄録全体を表示PDF形式でダウンロード (2297K) -
桂原稿種別: 本文
1960 年 19 巻 p. 132-
発行日: 1960年
公開日: 2017/12/22
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桂原稿種別: 本文
1960 年 19 巻 p. 132-
発行日: 1960年
公開日: 2017/12/22
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桂原稿種別: 本文
1960 年 19 巻 p. 132-
発行日: 1960年
公開日: 2017/12/22
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河合 文雄, 三好 歳雄, 満田 久輝原稿種別: 本文
1960 年 19 巻 p. 133-139
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThe fluorescent substances in wheat seedling were separated into two fractions by the florisil adsorption treatment ; the flavins and the others. The former fraction was further fractionated by the ion exchange resin (Dowex 1×4) column chromatography, and thus, the presence of riboflavin, FMN and FAD were confirmed but no other flavin compound was detected. The latter fraction was separated to about ten fluorescent spots by paper partition chromatography. Some eluates from these spots were converted to riboflavin in the presence of cell-free extract of Aerobacter aerogenes.抄録全体を表示PDF形式でダウンロード (637K) -
高田原稿種別: 本文
1960 年 19 巻 p. 139-
発行日: 1960年
公開日: 2017/12/22
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久野 真克原稿種別: 本文
1960 年 19 巻 p. 140-154
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThe effects of vitamin B_6 deficiency upon the pancreas and parotid gland of rats were studied clinically, histologically, and histochemically. In the rats fed on vitamin B_6 deficient diet for a long time, hyperglycemia and glycosuria were observed. Histologically, β-cells of Langerhans' islet fell in various degenerative changes and then it decreased. The atrophy and round cell infiltration fo exocrine part were evident in an advanced state of vitamin B_6 deficiency. The striated and terminal portions of parotid gland of vitamin B_6 deficient rats gradually became atrophic.抄録全体を表示PDF形式でダウンロード (2063K) -
上久保原稿種別: 本文
1960 年 19 巻 p. 154-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 19 巻 p. 154-
発行日: 1960年
公開日: 2017/12/22
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桂原稿種別: 本文
1960 年 19 巻 p. 154-
発行日: 1960年
公開日: 2017/12/22
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坂本 春成原稿種別: 本文
1960 年 19 巻 p. 155-160
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThe metabolic fate of rutin and quercetin by Penicillium brevi-compactum was studied. In this case protocatechuic acid and phloroglucinol carboxylic acid was found in the culture medium. Though rutih was metabolized by Penicillium link, quercetin itself did not showed any of metabolic product when it was added to the culture medium. The degradation of quercetin, however, occurred when glucose was added to the cultural solution and it was found the same result with rutin.抄録全体を表示PDF形式でダウンロード (591K)