抄録
In rabbits it was observed that thioctic acid restored the functions of bromsulfalein and thiobarbiturate detoxication which were lowered due to CCl_4 poisoning. In rats thioctic acid depressed to some degree the accumulation of fat in the chronic CCl_4 poisoning liver. The concentrations of pyruvic acid in blood of rabbits and rats with acute CCl_4 poisoning were significantly higher than normal animals. The administration of thioctic acid caused the depression in the elevation of pyruvic acid levels in both animals. The relative results were obtained for pyruvic acid level in rat liver. For α-ketoglutaric acid levels in blood and liver of rats no detectable difference was observed between CCl_4 poisoning and normal control. Although in rabbits α-ketoglutaric acid concentration in blood was elevated transitorily due to CCl_4 poisoning, thioctic acid did not influence the peak of this acid level.
