巻号一覧
20 巻
選択された号の論文の444件中1～50を表示しています
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宮田 善一原稿種別: 本文
1960 年 20 巻 p. 1-5
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーMeasurement was made on the riboflavin content and the percentage of 3 forms of riboflavin in the organs of rats which were suffered from glycosuria by administration of p-aminosalicylic acid and oxine injection. In the p-aminosalicylic acid administered rats, riboflavin content decreased in the kidney considerably, in the liver and heart slightly, and was unchanged in the pancreas and muscle. In the oxine diabetic rats, riboflavin content decreased remarkably in the liver, kidney and heart, but it did not decrease in the pancreas and muscle. No considerable change was observed in the percentage of 3 forms of riboflavin in the organs of the rats.抄録全体を表示PDF形式でダウンロード (499K) -
高田原稿種別: 本文
1960 年 20 巻 p. 5-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 20 巻 p. 5-
発行日: 1960年
公開日: 2017/12/22
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佐伯 久, 佐伯 昌子原稿種別: 本文
1960 年 20 巻 p. 6-14
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーAn experimental study was made on the changes of physiological functions and the dynamic aspects of thiamine metabolism caused by mental work under hot atmospheric stimulation for a relatively long time. The experimental subjects were 3 healthy men of 20-24 years old. Daily fluctuations in the total thiamine content of blood were observed even under normal conditions, and the content seemed to depend on the amount of the thiamine intake. After oral administration of thiamine, an increase of the level of free thiamine of the blood plasma occurred. This was soon followed by a rise of the level of esterified thiamine of the whole blood. Eventually, both gradually decreased and reached their original levels. Under hot atmospheric conditions for a relatively short time, the level of thiamine of blood was lowered, and free thiamine was not observed in the blood plasma. When a heat stress over the critical temperature (temperature at which a sudden rise of pulse over 100 is observed) was applied to a subject who had been subjected for 2-3 hours to a preliminary stress nearly at this temperature, a marked rise of the total thiamine level of blood was observed in at least 7-8 hours after the preliminary stress. Since no free thiamine was found in blood at this period, it seemed that the rise of the total thiamine level was due to the increase of the esterified form in the plasma. The free thiamine content of the urine increased during this period. When the stress was removed a marked increase was observed. Although seasonal variation seemed to play a role, the exact reason for this phenomenon has not yet been clarified. It was also found that the second heat stress exerted an inhibitory effect on the increase of free thiamine level.抄録全体を表示PDF形式でダウンロード (922K) -
高田原稿種別: 本文
1960 年 20 巻 p. 14-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 20 巻 p. 14-
発行日: 1960年
公開日: 2017/12/22
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野村 重彦原稿種別: 本文
1960 年 20 巻 p. 15-48
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThree groups of rats were fed respectively on low-phosphorus diet (McCollum No.3143 rachitic diet, Steenbock No.2965 rechitic diet, and its modified form), high-phosphorus diet (Steenbock No.2965 rachitic diet containing Na_2HPO_4 instead of CaCO_3), and a control diet. Then, radioisotopic experiments were carried out on the metabolisms of phosphorus and calcium in teeth and surrounding tissues, and effects of vitamin D_2 administration on their metabolisms. Metabolisms of calcium and phosphorus in the dental hard tissues resembled each other in exchange and accumulation on the tissues as same as in the bone tissues. However, some essential differences in behaviors of these elements were observed. Furthermore, the ratio of calcium to phosphorus of the diet, parts of the teeth and the lapse of time were found to cause the difference between calcium and phosphorus metabolisms. Effect of vitamin D_2 administration on the dental hard tissue was greater in the high-phosphorus diet group than the low phosphorus diet one. This effect was not proportional to the amount of administered vitamin D_2 or frequency of administration. A prolonged administration of vitamin D_2 sometimes brought about a decline of metabolism of inorganic matters.抄録全体を表示PDF形式でダウンロード (4239K) -
有井 義公原稿種別: 本文
1960 年 20 巻 p. 49-60
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーPresent report includes the studies on the tryptophan metabolism in the experimentally induced riboflavin deficient rats, administered with pyridoxal phosphate, pyridoxine and TPNH with simultaneous subcutaneous injection of FMN, investigating the urinary excretion of anthranilic acid, kynurenine, xanthurenic acid and N-methylnicotinamide after an oral administration of 50mg of _L-tryptophan. A considerable amount of anthranilic acid, xanthurenic acid and a small amount of N-methylnicotinamide was excreted in riboflavin deficient rats more than those of healthy control group, while kynurenine was almost unchanged. By the administration of FMN alone, the considerable decrease of the excretion of anthranilic acid and xanthurenic acid, and increase of the excretion of N-methylnicotinamide was observed, while kynurenine was unchanged. When pyridoxal phosphate or pyridoxine was given with FMN, xanthurenic acid excretion further decreased and N-methylnicotinamide increased more than in the simple administration of FMN, while anthranilic acid and kynurenine were unchanged. As for TPNH induction, no considerable difference was found except a slight decrease of kynurenine. Furthermore, the excretion of xanthurenic acid decreased in cases of the simple application of pyridoxal-phosphate and pyridoxine. In the control group, no appreciable difference was perceived.抄録全体を表示PDF形式でダウンロード (1065K) -
本多 文夫, 人見 正博, 富家 弘子, 渡辺 信夫原稿種別: 本文
1960 年 20 巻 p. 60-64
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーIn rabbits it was observed that thioctic acid restored the functions of bromsulfalein and thiobarbiturate detoxication which were lowered due to CCl_4 poisoning. In rats thioctic acid depressed to some degree the accumulation of fat in the chronic CCl_4 poisoning liver. The concentrations of pyruvic acid in blood of rabbits and rats with acute CCl_4 poisoning were significantly higher than normal animals. The administration of thioctic acid caused the depression in the elevation of pyruvic acid levels in both animals. The relative results were obtained for pyruvic acid level in rat liver. For α-ketoglutaric acid levels in blood and liver of rats no detectable difference was observed between CCl_4 poisoning and normal control. Although in rabbits α-ketoglutaric acid concentration in blood was elevated transitorily due to CCl_4 poisoning, thioctic acid did not influence the peak of this acid level.抄録全体を表示PDF形式でダウンロード (621K) -
高田原稿種別: 本文
1960 年 20 巻 p. 64-
発行日: 1960年
公開日: 2017/12/22
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本多 文夫, 人見 正博, 富家 弘子, 斎藤 純逸原稿種別: 本文
1960 年 20 巻 p. 65-69
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーPyruvate oxidation was low in liver slices of the rat with experimental CCl_4 poisoning. This activity was restored, significantly by in vivo treatment with thioctic acid. Similar results were obtained with mitochondria of liver cells. In vitro experiments, thioctic acid increased significantly the diminished pyruvate oxidation of liver slices of poisoned rats as was the case with cocarboxylase or coenzyme A, while the increase was very slight in normal liver slices. In both acute and chronic CCl_4 poisoning rats the thioctic acid contents of liver mitochondria were lower compared with those in normal animals.抄録全体を表示PDF形式でダウンロード (620K) -
片桐 学原稿種別: 本文
1960 年 20 巻 p. 70-80
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーExperiments on the phosphorylation were made with homogenate, mitochondria suspension fluid and supernatant fluid, all added with riboflavin, of various organs and the blood, using normal rabbits, normal and riboflavin-deficient mice. Phosphorylation of riboflavin was observed in livers, kidneys and small intestines of rabbits and mice and in the chicken blood. It took place in the mitochondria. Although, in small intestines, FMN alone was synthesized from riboflavin, the synthesis of FAD from riboflavin could be found in liver and kidneys. In small intestines glucose-1-phosphate, besides ATP, acted as a phosphate-donor.抄録全体を表示PDF形式でダウンロード (1047K) -
片桐 学原稿種別: 本文
1960 年 20 巻 p. 80-85
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーUsing normal rabbits, solutions of FMN and FAD and percolations of kidney and liver were added each to the blood and to the homogenate of kidneys, liver and small intestines. Riboflavin was measured after the incubation for 30 minutes at 37℃. On the other hand, blood was hourly taken from perpheral veins, renal arteries and renal veins of normal dogs sujected to intravenous injection of 5mg of riboflavin, FMN and FAD each and the riboflavin value in the blood was measured. In kidneys and blood the dephosphorylation of ribflavin was observed, but not in liver and small intestines. The kidney seems to play a very important role in the dephosphorylation of riboflavin.抄録全体を表示PDF形式でダウンロード (641K) -
高田原稿種別: 本文
1960 年 20 巻 p. 85-
発行日: 1960年
公開日: 2017/12/22
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水野 孝道, 河野 通易, 人見 恭一, 片岡 保男, 奥野 淳一原稿種別: 本文
1960 年 20 巻 p. 86-90
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーHistochemical investigations were carried out on the distribution of choline esterase activity in medulla oblongata of normal and thiamine deficient rats. Choline esterase in nucleus originis nervi hypoglossi and nucleus originis nervi facialis of normal rats was remarkably active while in nucleus ambigius, nucleus rhaphes magnus, nucleus olivae and formatio reticularis was moderately active. In thiamine deficient rats, choline esterase activity was decreased in nucleus originis nervi hypoglossi, nucleus originis nervi facialis and formatis reticularis.抄録全体を表示PDF形式でダウンロード (1481K) -
高田原稿種別: 本文
1960 年 20 巻 p. 90-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 20 巻 p. 90-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 20 巻 p. 90-
発行日: 1960年
公開日: 2017/12/22
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松井 清夫, 田添 浩一, 村上 不二雄原稿種別: 本文
1960 年 20 巻 p. 91-92
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーIn paper partition chromatography of thiamine, three methods were compared with each other, that is, using potassium ferricyanide, cyanogen bromide and phosphomolybdeic acid. It was found that potassium ferricyanide method was most sensitive for showing paper partition chromatography, followed by phosphomolybdeic acid method, and the cyanogen bromide method was the lowest in sensibility.抄録全体を表示PDF形式でダウンロード (263K) -
高田原稿種別: 本文
1960 年 20 巻 p. 92-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 20 巻 p. 92-
発行日: 1960年
公開日: 2017/12/22
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津野 貞子, 村上 不二雄, 田添 浩一, 菊本 聰原稿種別: 本文
1960 年 20 巻 p. 93-96
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThe authors have previously demonstrated the fact that a large amount of (+)-S-methyl-L-cysteine sulfoxide is distributed in the whole Allium and Colza plants. In the present experiment the authors succeeded in isolating this compound from raddish, cabbage, cauliflower, turnip and Chinese cabbage among the Cruciferae and from scallion in the Allium. This substance had a melting point of 173-174℃, could be converted into NH_3,pyruvic acid and methyl allicin by alliinase and is converted to thiamine methyldisulfide by the addition of thiamine. This extract was regarded as the same compound as that reported by Synge et al. The authors designated it as "methiin".抄録全体を表示PDF形式でダウンロード (514K) -
高田原稿種別: 本文
1960 年 20 巻 p. 96-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 20 巻 p. 96-
発行日: 1960年
公開日: 2017/12/22
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田添 浩一原稿種別: 本文
1960 年 20 巻 p. 97-101
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThe effect of allithiamine and other vitamins on acute hydrocyanic acid poisoning was examined on dd-strain mice. Thiamine propyldisulfide and the garlic extract were effective against acute hydrocyanic acid poisoning. Thiamine hydroxyethyldisulfide and thiamine tetrahydrofurfuryldisulfide were not so effective as the previous substances. Thiamine hydrochloride had no effect.抄録全体を表示PDF形式でダウンロード (473K) -
田添 浩一原稿種別: 本文
1960 年 20 巻 p. 102-104
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーFor measuring the activity of mouse liver rhodanese, the following procedures were found to be most appropriate. After homogenizing the mouse liver, the supernatant layer was employed as the enzyme solution. This solution (1.0 cc) was added with 2.0 cc of 1% NaCN, 0.1 NNa_2S_2O_3,20.0 cc of PH 8.2 phosphate buffer and 30.0 cc of distilled water. It was kept at 38℃ for 2 hours, and deproteinized by trichloracetic acid. After such procedures, the orange color that was brought about by the ferri-reagent was measured by photometer.抄録全体を表示PDF形式でダウンロード (342K) -
田添 浩一原稿種別: 本文
1960 年 20 巻 p. 105-111
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーIn order to observe the counteracting effect of allithiamine on acute hydrocyanic acid poisoning, the influence of allithiamine and other vitamins upon the action of liver rhodanese in vivo and in vitro with dd-strain mice. In vi o, thiamine propyldisulfide and vitamin B_6 promoted the action of liver rhodanese and vitamin K suppressed it.抄録全体を表示PDF形式でダウンロード (656K) -
田添 浩一原稿種別: 本文
1960 年 20 巻 p. 112-122
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThe author examined the influence of garlic and related sulfur-containing amino acids upon liver rhodanese by using dd-strain mice. It was recognized that garlic extract, allicin, alliin, cysteine and methionine had the effect of promoting the action of mouse liver rhodanese. As for the amino acids which do not contain sulfur, no promoting effect was perceived.抄録全体を表示PDF形式でダウンロード (940K) -
村上 不二雄, 田添 浩一原稿種別: 本文
1960 年 20 巻 p. 123-125
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーAs the authors found that allithiamine and garlic extract were effective against acute hydrocyanic acid poisoning, their effects upon the oxygen consumption of liver slices were observed with the Warburg's manometer. Thiamine, thiamine propyldisulfide, garlic extract and other vitamins did not exhibit almost any influence on normal liver tissue respiration, but in acute hydrocyanic acid poisoning they were proved to recover the liver tissue respiration.抄録全体を表示PDF形式でダウンロード (327K) -
村上 不二雄原稿種別: 本文
1960 年 20 巻 p. 126-131
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーAlthough it was previously shown that in the Allium plants, alliinase alone had the enzymatic effect decomposing alliin homologues into allicin, pyruvic acid and ammonia, the author discovered that the microorganisms, especially Bacillus subtilis, had also the same activity as alliinase, and investigated the suitable conditions of allicin formation by the microorganism.抄録全体を表示PDF形式でダウンロード (587K) -
村上 不二雄原稿種別: 本文
1960 年 20 巻 p. 131-135
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThe acetone-powdered enzyme of Bacillus subtilis, prepared by the author, was found to decompose alliin or methiin, and produce thiamine allyldisulfide or thiamine methyldisulfide. The enzymatic activity was depressed or counteracted by addition of metaphosphoric acid and potassium cyanide, respectively, or merely by heating procedure. The optimum pH of the activity was about 7.0 and the optimum temperature was 37℃.抄録全体を表示PDF形式でダウンロード (576K) -
藤原 邦達, 村上 不二雄原稿種別: 本文
1960 年 20 巻 p. 136-139
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThe author found that when allicin was added to denaturated egg albumin and human or rabbit blood, it easily combined with protein to form an allicin-protein complex, and made clear that allithiamine was formed up from this allicin-protein complex by the addition of thiamine in vitro and in vivo.抄録全体を表示PDF形式でダウンロード (400K) -
藤本 達郎, 田辺 裕文, 内田 雅夫, 柴 昇, 草野 真郎, 柵山 富士雄, 季家 栄, 吉田 之好原稿種別: 本文
1960 年 20 巻 p. 140-150
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThe amount of riboflavin excreted in three hour urine at rest in diabetic patients was much more than that of normal subjects, and it tended to decrease with the fall of blood sugar level by medical treatment. The urinary excretion of riboflavin increased by the administration of glucose, ATP or glucose with ATP both in normal and diabetic subjects. By the intravenous injection of insuline, it was observed a fall of riboflavin level in blood, an increase of urinary excretion of riboflavin and a rise of riboflavin concentration of urine.抄録全体を表示PDF形式でダウンロード (1095K) -
高田原稿種別: 本文
1960 年 20 巻 p. 150-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 20 巻 p. 150-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 20 巻 p. 150-
発行日: 1960年
公開日: 2017/12/22
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柳井 哲雄原稿種別: 本文
1960 年 20 巻 p. 151-155
発行日: 1960年
公開日: 2017/12/22
ジャーナル フリーThiamine synthesis from pyrimidine- and thiazole moieties by washed cells of several strains of Enterobacteriaceae was studied. In the case of Escherichia coli ATCC 9637,a good yield of thiamine was obtained when the reaction was carried out under an aerated condition in the presence of glucose. The synthesized vitamin was almost exclusively in esterified form and was practically restricted intracellularly. Among 3 strains of thiamine requireing mutants derived from E.coli ATCC 9637,only 70-23,which required intact thiamine, failed to synthesize an appreciable amounts. Strains 70-17 and 26-43,each of which was capable of growing in the presence of pyrimidine- or thiazole moiety respectively, synthesized much more amount of thiamine than their parent strain. All but one (a strain of Shigella dysenteriae 1) of strains examined which belong to Shigella or Alkalescens・Dispar groups were also found to synthesize thiamine from pyrimidine- and thiazole moieties. The yield of the vitamin was greatly improved by the aeration of the reaction mixture.抄録全体を表示PDF形式でダウンロード (560K) -
高田原稿種別: 本文
1960 年 20 巻 p. 155-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 20 巻 p. 155-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 20 巻 p. 155-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 20 巻 p. 155-
発行日: 1960年
公開日: 2017/12/22
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原稿種別: 付録等
1960 年 20 巻 p. 156-
発行日: 1960年
公開日: 2017/12/22
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原稿種別: 付録等
1960 年 20 巻 p. 156-
発行日: 1960年
公開日: 2017/12/22
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原稿種別: 付録等
1960 年 20 巻 p. 156-
発行日: 1960年
公開日: 2017/12/22
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原稿種別: 付録等
1960 年 20 巻 p. 157-
発行日: 1960年
公開日: 2017/12/22
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原稿種別: 付録等
1960 年 20 巻 p. 157-
発行日: 1960年
公開日: 2017/12/22
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原稿種別: 付録等
1960 年 20 巻 p. 157-
発行日: 1960年
公開日: 2017/12/22
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原稿種別: 付録等
1960 年 20 巻 p. 157-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 20 巻 p. 158-
発行日: 1960年
公開日: 2017/12/22
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高田原稿種別: 本文
1960 年 20 巻 p. 158-
発行日: 1960年
公開日: 2017/12/22
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