抄録
Influences of daily administration of, a large amount of thiamine propyldisulfide (TPD) to rats with feed for 2 months were investigated by the growth of rats, the contents of riboflavin and thiamine in livers, and xanthine oxidase and D-amino acid oxidase activities of livers. TPD 3 mg per rot per day as a large amount, were given to two groups of rats, i. e., a riboflavin deficient group and a group with riboflavin 7-8μg/rat/day, and the results were compared with those of the groups given TPD 30μg/rat/day, as a regular amount respectively to the riboflavin deficient group or the group of 7-8μg/rat/day. The results obtained showed that administration of the large amount of TPD to the riboflavin deficient rats did not give any aggravating effect upon the growth of rats, thiamine or riboflavin contents and enzyme activities of livers. Rather a progressive effect was observed when the large amount of TPD was given to the group of rats fed riboflavin 7-8μg/rat/day.
