γ-アミノ酪酸の代謝にかんする研究 : β-オキシ-γ-アミノ酪酸の生成および負荷試験
1962 年 25 巻 4 号 p. 266-277
詳細
1962 年 25 巻 4 号 p. 266-277
Experimental loading of γ-aminobutyric acid or β-hydroxy-γ-aminobutyric acid ar intravenous injection in rabbits following pretreatment with isonicotinic hydrazide resulted in the production of β-hydroxy-γ-aminobutyric acid in the case of γ-aminobutyric acid and glycine in the case of β-hydroxy-γ-aminobutyric acid. These products however were not obtained when pyridoxine was given concomitantly. A pathway from γ-aminobutyric acid to glycine via the β-hydroxy form was therefore shown to exist but in the normal state, it is believed that a more active metabolic pathway involving vitamin B_6 is present.
