抄録
The level of lipoic acid activity in blood after the intravenous injection of TATD was higher and long lasting than after the injection of lipoic acid. This high activity in blood was predominantly distributed in the plasma fraction and a considerable part of its activity was found to be combined with plasma protein. Namely, when the plasma after 30 minutes of the injection of TATD was treated with ethanol or 5% metaphosphoric acid to precipitate the protein, about 30% of the activity in the plasma was found in this protein fraction. Thus, the combination of the lipoate moiety with the plasma protein should be responsible for the long maintenance of the high activity in blood after the injection of TATD.
